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"olaparib" Word Dosyaları

  • Purpose of Application - pbs.gov.au

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    Additionally the price for olaparib was estimated for the trial-based economic evaluation that would maintain an ICER of 45 000 QALY - 75 000 QALY see Table 5 .

  • Purpose of Application - pbs.gov.au

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    Olaparib was considered to have fewer side effects compared with chemotherapy. The PBAC noted the advice received from Medical Oncology Group of Australia ...

  • moqc

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    Olaparib is an oral medicine that your doctor prescribed for the treatment of your cancer. Please take your olaparib as directed by your prescriber.

  • velindrecc.wales.nhs.uk

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    Olaparib is a cancer treatment which is given as capsules. Why am I having . olaparib Olaparib has been found to help some patients with your type of cancer. H.

  • 1380 Final PSD - msac.gov.au

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    Public Summary Document. Application No. 13. 8. 0 BRCA mutation testing to determine eligibility for olaparib mainte. nance therapy in patients with

  • MATERIALS AND METHODS - Nature

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    The next day cells were exposed to olaparib at 2-fold concentrations ranging from 20 M down to 0.08 M diluted in in growth-factor free medium ...

  • İlgili Makama - kanser

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    Olaparib . bir PARP-inhibitörüdür. BRCA mutasyonu olan ve daha önce 3 veya daha fazla tedavi almış olan nüks over kanserli hastalarda kullanılması FDA ...

  • nature

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    Effects of olaparib on cell growth in the presence and absence of Parp1. Figure S3. Activation of endogenous E2F-dependent transcription by BIN1 depletion . Figure S4.

  • researchgate

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    Indoleamine 2 3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib gamma radiation and cisplatin. Appendix A. Supplementary material

  • static-content.springer

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    Online resource 1. An adaptive study to determine the optimal dose of the tablet formulation of the PARP inhibitor olaparib. J Mateo V Moreno A Gupta SB Kaye E ...

  • crcwm

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    Patients must not have had prior exposure to any agent with a PARP inhibitor e.g. veliparib olaparib rucaparib niraparib talazoparib BMN 673 ...

  • Equality Screening Northern Ireland Arrangements for ...

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    Equality Questionnaire Northern Ireland Arrangements for Assessing Applicability of NICE Guidance to the HSC Sector. Olaparib. for maintenance treatment of relapsed ...

  • mct.aacrjournals

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    MTT cell viability relative absorbance values across multiple cell lines after a 7-day incubation with Veliparib Olaparib or Niraparib.

  • nar.oxfordjournals

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    NIH 3T3 cells with shMock or shARTD1 was performed treated with ActD 50 ng ml 20 h MNNG 500 M 30 min and Olaparib 10 M 3 h . Supplementary Figure 5.

  • researchgate

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    ... pre-fixation Pacific Orange-staining substituted the TUNEL-assay in these experiments . Reh cells treated with 3 M olaparib PARP inhibitor and 10 M KU ...

  • facingourrisk

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    ... Guidelines Version2.2015 for Epithelial Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer recommend olaparib as a targeted therapy as a single agent ...

  • DUR Prospective Drug Use Review - Section 20 20 d00

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    Prospective DUR target drugs are select drugs subject to the online Medi-Cal prospective DUR screening ... Olaparib. Olmesartan. Omacetaxine. Omeprazole. Orlistat ...

  • BIO360 The Molecular Biology of Cancer

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    BIO360 The Molecular Biology of Cancer. ... Yet the graph on the right side of Figure 5A seems to show that olaparib treatment roughly doubles the levels of FADD

  • DUR Appendix A Duplicate Therapy Section 25 25_d00

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    ... mitotane mitoxantrone necitumumab nelarabine nilotinib nilutamide nivolumab obinutuzumab ofatumumab olaparib omacetaxine osimertinib oxaliplatin ...

  • mass.gov

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    Lynparza olaparib PA. Mircera methoxy polyethylene glycol epoetin beta ...

  • SUPPLEMENTARY FIGURE LEGENDS - nar.oxfordjournals

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    Olaparib inhibits EGF-dependent pADP-ribosylation. Figure S8 related to Figure 6 . PARP-1 enzymatic activity is required to restart post-mitotic transcription.

  • swbh.nhs.uk

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    A Phase III Randomised Double Blind Placebo Controlled Multicentre Study of Olaparib Maintenance Monotherapy in Patients with BRCA Mutated Advanced ...

  • AR Medicaid DUR Board edits approved at the April 15 2015 ...

    Döküman Türü : Word Dökümanı
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    LYNPARZA OLAPARIB 50 MG CAPSULE Lynparza is indicated as monotherapy in patients with deleterious or suspected deleterious germline BRCA mutated ...

  • allianceforclinicaltrialsinoncology

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    OLYPMIA Olaparib Study Update. 11 35 Laura Esserman by phone robsonm mskcc I-SPY3 Proposal. 12 00pm Close. Author Partners Information Systems Created Date

  • Regimen s - link.springer

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    BRCA Olaparib No 21 Ovarian BRCA-mutation 16 BRCA-mutated 15 evaluated for response 9 15 Radiologic or CA-125response or SD Phase I study 137 1.

  • h - sinai

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    Olaparib Placebo BRCA testing provided Active. Leiomyosarcoma. Trial Diagnosis Schema Drugs Provided Status GOG-0277. High-Grade Uterine . Leiomyosarcoma ...

  • NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE

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    ... olaparib Celgene paclitaxel Eli Lilly gemcitabine Hospira UK carboplatin cisplatin gemcitabine topotecan Janssen-Cilag pegylated liposomal doxorubicin ...

  • North of Tyne Area Prescribing Committee - Minutes

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    SSC1608 NICE Technology Appraisal 381 Olaparib for maintenance treatment of relapsed platinum-sensitive BRCA mutation-positive ovarian ...

  • 1 - bioscience

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    Olaparib AZD-2281 is a potent orally administered PARP inhibitor Ki 5 nM and 1 nM for PARP-1 and 2 respectively with preclinical evidence of in vitro and in ...

  • rwjhamilton

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    ... Placebo-Controlled Multi-Centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients with Germline ...

  • cnas.ro

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    ... tuse şi febr sau dac se observ o modificare la examenul radiologic tratamentul cu olaparib trebuie ntrerupt şi trebuie luate m suri imediate ...

  • Cell dna vj free - zmi.syobq.mobi

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    Olaparib AZD2281 KU0059436 is a selective inhibitor of PARP1 2 with IC50 of 5 nM 1 nM in cell-free assays 300-times less effective against tankyrase-1.

  • MED-LIST - sites.google

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    Olaparib. PARP Poly ADP-ribose-Polymerase -Hemmer. BRCA-mutiertes Ovarial- Peritonealcarcinom.50 mg Kaps. Dosierung 2x8 Kaps. Lyrica . Pregabalin.

  • future-science

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    Cediranib maleate and olaparib in treating patients with recurrent ovarian fallopian tube or peritoneal cancer or recurrent TNBC. Phase I II. NCT01116648 5

  • Attachment B - canceraustralia.gov.au

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    Phase II clinical trial of the PARP inhibitor olaparib in HR- deficient advanced breast and ovarian cancer in women without inherited BRCA1 or BRCA2 mutations.

  • rwjhamilton

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    ... Placebo-Controlled Multi-Centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients with Germline ...

  • Date

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    TA381 Olaparib for maintenance treatment of relapsed platinum-sensitive BRCA mutation-positive ovarian ...

  • cancerres.aacrjournals

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    ... and treated with increasing concentrations PARP inhibitor PARPi Olaparib KU0058948 . Untransfected and VU-SCC-147 cells transfected with non-targeting siRNA ...

  • Title of Application - msac.gov.au

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    Olaparib inhibits the activation of PARP1 and PARP2 which are essential for the repair of single-strand DNA breaks via the base excision repair pathway.

  • A Randomised Phase III Trial To Determine The Role Of Fdg ...

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    Phase II Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer.

  • Attachment B - canceraustralia.gov.au

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    ICON9 A phase 3 randomised trial of cediranib and olaparib maintenance in patients with relapsed platinum sensitive ovarian cancer. Funded by Cancer Australia.

  • ittumori.it

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    Oral poly ADP-ribose polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer a proof-of-concept trial.

  • List of Natioanl Advisory Group Recommendations since ...

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    June 2015 1047 15 olaparib 50mg ... List of Natioanl Advisory Group Recommendations since April 2002 Author AILEENM Last modified by sandram Created Date

  • kclpure.kcl.ac.uk

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    ... polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer a proof-of-concept trial. Tutt A. Robson M. Garber J. E ...

  • Paper 020 - lmslifeline

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    Trabectedin once a week e.v. for 4 weeks iii olaparib i.p. for 5 days a week for. 4 weeks iv the combination of the two. significantly reduced tumor gowth of.

  • Clinical trials list long main section

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    STOMP Small cell lung cancer Trial of Olaparib AZD2281 as Maintenance Programme a randomised double blind multicentre phase II trial AD NIHR ON 2014 4506.

  • link.springer

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    PARP inhibition by olaparib effectively protected CLL cells from cell death through the most efficient MCNA Huni132 and Me-N69 both p 0.02 .

  • TAG Mail 30 November 2007 - Clinical Information Access ...

    Döküman Türü : Word Dökümanı
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    -- Lynparza olaparib to treat advanced ovarian cancer. http fda.gov Drugs NewsEvents ucm130958.htm-- new antibacterial drug Zerbaxa ceftolozane tazobactam

  • astrazeneca

    Döküman Türü : Word Dökümanı
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    Olaparib. Naropin 10 mg ml Injektionslösung . Ropivacain. Naropin 2 mg ml Injektionslösung Infusionslösung. Ropivacain. Naropin 5 mg ml - Injektionslösung .

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"olaparib" PDF Dosyaları

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"olaparib" PowerPoint Dosyaları

  • FDA DOSSIER LYNPARZA Olaparib - Universit Lille 2

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    FDA DOSSIER LYNPARZATMOlaparib. MASTER 2 AREIPS. ... Olaparib. Chemotherapeutic regimens platinum agent carboplatin or cisplatin taxane paclitaxel or docetaxel

  • PowerPoint Presentation

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    Approve olaparib for maintenance treatment. Insurance is likely to pay for drug if a woman meets criteria above ... PowerPoint Presentation Last modified by

  • Perspectives on PARP Inhibitors in Ovarian Cancer Has the ...

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    Olaparib as Maintenance Therapy Study Design. Results of BRCA Testing. Results. ASCO 2014 Cediranib Olaparib. PFS With Cediranib Olaparib Superior to Olaparib Alone.

  • Main Title Slide Always use Title Case on Slide Titles

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    Can We Define Tumors That Will Respond to PARP Inhibitors A Phase II Correlative Study of Olaparib in Advanced Serous Ovarian Cancer and Triple-Negative Breast Cancer

  • Strategies for Treatment of Relapsed Ovarian Cancer - GOG

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    Strategies for Treatment of Relapsed Ovarian Cancer Author armstde Last modified by Armstde Created Date 9 15 1999 7 52 08 PM Document presentation format

  • What Does BRCA Have to Do With It PARP Inhibitors in ...

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    Olaparib Maintenance Therapy. Velaparib in Patients With Recurrent Disease. ... What Does BRCA Have to Do With It PARP Inhibitors in Ovarian Cancer Last modified by

  • Gemifloxacin

    Döküman Türü : Word Dosyası
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    Contents. Drug. Gemcitabine Anti Cancer Drug Paper. J. Med. Chem. 2009 52 6958 6961. Synthesis. Gemcitabine Synthesis. Eli Lilly

  • PowerPoint Presentation

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    PARP Inhibitor Olaparib. References. H. Yang et al. BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure ...

  • Clinical Trials - Dana-Farber Cancer Institute

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    Olaparib is known as a PARP inhibitor. Ovarian Cancer. This is an antibody that has chemo linked to it. It delivers the chemo directly to the cancer cells that have ...

  • PowerPoint Presentation

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    Olaparib. HDAC. belinostat. entinostat. vorinostat. Topoisomerases. LMP400 776. Alkylating. Dimethane. sulfonate. Methylation . inh. FdCyd THU. TRC102. CTLA44 ...

  • CTEP Early Drug Development

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    Olaparib. HDAC. belinostat. entinostat. vorinostat. Topoisomerases. LMP400 776. Alkylating. Dimethane. sulfonate. Methylation inh. FdCyd THU. TRC102. CTLA44 ...

  • mct.aacrjournals

    Döküman Türü : Word Dosyası
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    Efficacy of olaparib as a single agent or in combination with radiation therapy on tumor vascular perfusion assessed by using a Calu-6 tumor DWC model.

  • Merck Serono - Moodle - Universit Lille 2

    Döküman Türü : Word Dosyası
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    To Merck Serono to develop and commercialize Fibroblast Growth Factor 18 and the genetic fusion molecule Atacicept. Partnership. with. BMS. Merck. Serono s. future.

  • mct.aacrjournals

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    RAD51C expression affects olaparib sensitivity in human cancer cell lines. Ahrum Min et al. Mol Cancer Ther 2013 12 865-877 2013 by American Association for Cancer ...

  • mcr.aacrjournals

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    Cotreatment of SAHA and olaparib synergistically decrease cell viability in prostate cancer cells. Olivia S. Chao and Oscar B. Goodman Jr Mol Cancer Res 2014 12 ...

  • PowerPoint Presentation

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    Nrg gog trials -nrg gy001 - cabozantinib-nrg gy003 nivolumimab - ipilumimab -nrg gy004 olaparib platinum sensitive ov ca-nrg gy005 cediranib platinum ...

  • Research To Practice

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    Press Release October 26 2016Positive results from the Phase III SOLO-2 trial to determine the efficacy of Olaparib 300 mg BID as monotherapy for the ...

  • cancerdiscovery.aacrjournals

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    ... olaparib-resistant tumors from KB1PM1 KB1PM3 and KB1PM4 either untreated or treated with AZD2461. C Kaplan Meier curve showing survival of mice with a Pgp- ...

  • cancerdiscovery.aacrjournals

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    Joaquin Mateo MD explains the findings of a phase II trial of the PARP inhibitor olaparib in patients with metastatic castration-resistant prostate cancer.

  • mcr.aacrjournals

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    Sensitivity of prostate cancer and normal prostate epithelial cells to SAHA and olaparib. Olivia S. Chao and Oscar B. Goodman Jr Mol Cancer Res 2014 12 1755-1766

  • Novel Targets and Therapies in Clinical Trials for ...

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    Cell Lines to AZD-2281 Olaparib Lowery MA Moynahan ME MSKCC Stage IV Panc with BRCA1187delAG Mutation Response to Gemcitabine AZD-2281.

  • Ovarian cancer .. in 15 minutes - Family Doctor

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    Olaparib. HNPCC. Lynch syndrome. MLH1 MSH2. 30 lifetime risk of ovarian cancer. Commonest initial presentation in women. Pre menopausal endometrial cancer. 80 ...

  • New Therapies for Metastatic Breast Cancer

    Döküman Türü : Word Dosyası
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    New Therapies for Metastatic Breast Cancer. Sigrun Hallmeyer MD. Oncology Specialists SC. Director Oncology Specialists Research Institute. Chair Cancer Committee ...

  • Neoadjuvant Trial Schema - collaboration.aacr

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    Olaparib monotherapy in patients with advanced cancer and a germline. BRCA1 2 . Mutation. Kaufman B et al. J ClinOncol 2015 33 244-250. Single Agent Olaparib in ...

  • stm.sciencemag

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    ... drug sensitivity of four different cell lines with proteomic profile changes after treatment with cisplatin and olaparib. IC50 values black bars ...

  • Title

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    SOLO 1 and 2 olaparib Randomised maintenance trials in first line and platinum-sensitive recurrent . BRCA. movarian cancer. NOVA niraparib

  • RNA interference as a resistance mechanism against crop ...

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    Inhibition of DNA PK enhances survival in olaparib treated MCL cells.A B.Granta 519 A or UPN2 ...

  • PowerPoint Presentation

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    Olaparib. PCR sanger. Myriad. EGFR protein. CRC. cetuximab panitumumab. IHC. Dako. C-Kit protein. GIST. imatinib. IHC. Dako. HER2 . Breast GEJ. trastuzumab ...

  • PowerPoint Presentation

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    Figure 1 RECIST response to olaparib by disease type Coleman R. L. 2015 Insights into strategies for optimizing ovarian cancer care Nat. Rev. Clin. Oncol. doi 10 ...

  • PowerPoint Presentation

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    Representative images of Olaparib treated tumors display induction of DSBs after 24 hour of incubation with 10 M Olaparib. Blue DAPI Green 53BP1 ...

  • Slide 1

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    Figure 3 Immunohistochemical and FISH findings of the on-study biopsy Forster M. D. et al. 2011 Treatment with olaparib in a patient with PTEN-deficient ...

  • Slide 1

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    Figure 5 14-day colorimetric assay for in vitro cytotoxicity to a PARP inhibitor KU0058948 Forster M. D. et al. 2011 Treatment with olaparib in a patient with ...

  • Reasons for testing - SWSCN

    Döküman Türü : Word Dosyası
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    Why BRCA testing in the SW should be reviewed now. A new treatment olaparib has recently been recommended by NICE ID735 final publication pending

  • thelancet

    Döküman Türü : Word Dosyası
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    NICE guidance on olaparib for maintenance treatment of patients with relapsed platinum-sensitive BRCA mutation-positive ovarian cancer Helen Tucker Zoe Charles ...

  • Genomics proteomics and other omics in cardiovascular ...

    Döküman Türü : Word Dosyası
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    Identifies presence absence of BRAC1 2 mutations in tumours of OC pts currently denied treatment with PARP inhibitors olaparib . Utility

  • PowerPoint - gynecologiconcology-online

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    Figure S2. A. B. C. Vehicle. Olaparib. RAD001. RAD Ola. Fig. S2 The dual inhibition . mTOR. pathway and PARP resulted in induced . DNA . damage and . impaired ...

  • CANCER DE MAMA 3N - samas.ar

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    Olaparib - NCT02000622 . Selective tumor cell killing. Increased. normal tissue toxicity. predicted. ... CANCER DE MAMA 3N Last modified by LAPT Clock 3 Company

  • PowerPoint Presentation

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    Olaparib Astra Zeneca PO. Veliparib ABT888 - Abbvie PO. BMN-673 Biomarin PO. Niraparib MK-4827 PO. CEP 9722 Cephalon PO. GPI 21016 MGI Pharma PO.

  • RNA interference as a resistance mechanism against crop ...

    Döküman Türü : Word Dosyası
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    When olaparib is used in combination with SAHA SAHA blocks the HR mediated repair pathway which is needed for repairing the DSBs induced by olaparib ...

  • science.sciencemag

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    ... CETSA curves in lysates with the PARP-1 inhibitors olaparib and iniparib and E the corresponding ITDRFCETSA at 50 C. Data are presented as means SEM ...

  • Title of presentation in 46pt Arial Bold in Mulberry ...

    Döküman Türü : Word Dosyası
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    Olaparib. Selumetanib. AZD9291. Tenormin. Hypertension. Diprivan. General anaesthetic. Tomudex. CRC. Inderal. Propranolol. Author klzp232 Created Date 05 06 2010 03 ...

  • gynecologiconcology-online

    Döküman Türü : Word Dosyası
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    Efficacy and safety of olaparib monotherapy in germline BRCA1 2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy

  • PowerPoint Presentation

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    General principles. ER PR positive Her2 negative - symptomatic visceral dz rapidly progressing chemo 1-2 drugs for 4-6 months change to AET - asymptomatic low ...

  • Slide 1

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    ROCOCO Radiotherapy olaparib for oesophageal carcinoma. 5. SIEGE. 13. SORAMIC. 1. ST03. 94. TACE-2. 7. Kent Surrey and Sussex. Study Name. Total Recruitment ...

  • PowerPoint Presentation

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    Olaparib. Veliparib. Rucaparib. Niraparib. BMN-673. Tutt et al Lancet. 2010. Audeh et al Lancet. 2010. Gelmon et al Lancet Oncology . 2011. Treatment of . BRCA1 2 ...

  • 1 - pptdown.cnd8

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    Olaparib - PARP1 PARP2 PARP3 PARP DNA ...

  • SPECIALTY RX - WI Health Plans

    Döküman Türü : Word Dosyası
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    The Specialty Rx pipeline is rich and more transformative products that share many of the characteristics of ... olaparib. BRCA mutation-positive ovarian cancer. ...

  • Five inhibitors That in White Powder Form - slideboom

    Döküman Türü : Word Dosyası
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    Olaparib. Olaparib also known as AZD-2281 or KU-59436 is a small molecule inhibitor of the nuclear enzyme poly ADP-ribose polymerase PARP with potential ...

  • omicsgroup

    Döküman Türü : Word Dosyası
    Kısa Özet :

    Olaparib. 10. M. M028 ...

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